Protein production using processed cell lysates is a core technology in synthetic biology and
these systems are excellent to produce difficult toxins or membrane proteins. However, the …

Obesity and metabolic syndrome are associated with several cancers, however, the
molecular mechanisms remain to be fully elucidated. Recent studies suggest that …

Caveolin-1 (Cav1), a major Src kinase substrate phosphorylated on tyrosine-14 (Y14),
contains the highly conserved membrane-proximal caveolin scaffolding domain (CSD; …

We investigated new transcription and splicing factors associated with the metastatic
phenotype in colorectal cancer. A concatenated tandem array of consensus transcription …

Chronic overnutrition, for instance, high-fat diet (HFD) feeding, is a major cause of rapidly
growing incidence of metabolic syndromes. However, the mechanisms underlying HFD …

Colorectal cancer (CRC) is the second deadliest cancer worldwide. Here, we aimed to study
metastasis mechanisms using spatial proteomics in the KM12 cell model. Cells were SILAC …

Acute ischemic stroke (AIS) is a devastating cerebrovascular disorder that leads to
permanent physical and neurological disabilities in adults worldwide. Proteins associated …

Reversible cysteine modifications play important physiological roles such as modulating
enzymatic catalysis, maintaining redox homeostasis and conducting cellular signaling …

PTPRJ, a receptor protein tyrosine phosphatase strongly downregulated in human cancer,
displays tumor suppressor activity by negatively modulating several proteins involved in …

Cysteine-selective proteomics approaches simplify complex protein mixtures and improve
the chance of detecting low abundant proteins. It is possible that cysteinyl-peptide/protein …