Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Over the past decade, synthetic biology has emerged as an engineering discipline for
biological systems. Compared with other substrates, biology poses a unique set of …

Protein switches are ubiquitous in biological signal transduction systems, enabling cells to
sense and respond to a variety of molecular queues in a rapid, specific, and integrated …

Engineering mammalian cell-based devices that monitor and therapeutically modulate
human physiology is a promising and emerging frontier in clinical synthetic biology …

Switchable proteins that can be regulated through exogenous or endogenous inputs have a
broad range of biotechnological and biomedical applications. Here we describe the design …

The ubiquitin-proteasome pathway (UPP) is the main route of protein degradation in
eukaryotic cells and is a common mechanism through which numerous cellular pathways …

Abstract Domain recombination is a key principle in protein evolution and protein
engineering, but inserting a donor domain into every position of a target protein is not easily …

Bacteria-based networks are formed using native or engineered bacteria that communicate
at nano-scale. This definition includes the micro-scale molecular transportation system …

Protein engineering holds the potential to transform the metabolic drug landscape through
the development of smart, stimulusresponsive drug systems. Protein therapeutics are a …

Activity of allosteric protein catalysts is regulated by an external stimulus, such as protein or
small molecule binding, light activation, pH change, etc., at a location away from the active …