Recent studies have shown that peripheral nerves play an important role in the progression
of breast cancer. Breast cancer cells (BCCs) promote local peripheral nerve growth and …

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt to their environment
by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth and …

Background Accumulating studies have shown that tumors are regulated by nerves, and
there is abundant nerve infiltration in the tumor microenvironment. Many solid tumors …

Simple Summary Medical control of cancer pain is often unsatisfactory. Narcotic drugs
(opioids) are effective pain killers, but they have important negative effects on the central …

Both sensory neurons and immune cells, albeit at markedly different levels, express the
vanilloid (capsaicin) receptor, Transient Receptor Potential, Vanilloid-1 (TRPV1). Activation …

Introduction Patients developing acute radiotherapy induced dermatitis or oral mucositis
commonly experience pain. When severe, this radiotherapy-associated pain (RAP) can …

Capsaicin is the main compound responsible of the hot sense of the chili fruits. This
compound has interesting therapeutic properties including anticancer, anti-inflammatory …

With an estimated 2 billion chili pepper connoisseurs worldwide, the human exposure to
capsaicin is enormous. Therefore, the question whether nutritional capsaicin is a cancer …

Oedema formation and polymorphonuclear leukocyte (neutrophil) accumulation are
involved in both acute and chronic inflammation. Calcitonin gene-related peptide (CGRP) is …

Simple Summary Bone cancer-related chronic pain is mediated by central sensitization
involving neuroinflammation via glial cell activation in the spinal dorsal horn, but not the …