Post-translational modifications: regulators of neurodegenerative proteinopathies

R Gupta, M Sahu, D Srivastava, S Tiwari… - Ageing Research …, 2021 - Elsevier
One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

[HTML][HTML] Unravelling the in vitro and in vivo potential of selenium nanoparticles in Alzheimer's disease: A bioanalytical review

D Vicente-Zurdo, N Rosales-Conrado… - Talanta, 2024 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
progressive cognitive decline and the accumulation of beta-amyloid plaques and tau tangles …

Peroxisome proliferator-activated receptor-γ ameliorates neuronal ferroptosis after traumatic brain injury in mice by inhibiting cyclooxygenase-2

H Liang, T Tang, H Huang, T Li, C Gao, Y Han… - Experimental …, 2022 - Elsevier
Among the multiple kinds of neuronal cell death triggered by traumatic brain injury (TBI),
ferroptosis, an iron-dependent lipid peroxidative regulatory cell death, has a critical role …

Serum d-serine levels are altered in early phases of Alzheimer's disease: towards a precocious biomarker

L Piubelli, L Pollegioni, V Rabattoni, M Mauri… - Translational …, 2021 - nature.com
Abstract d-Serine acts as a co-agonist of N-methyl-d-aspartate receptors (NMDAR) which
appear overactivated in AD, while d-aspartate is a modulatory molecule acting on NMDAR …

[HTML][HTML] Interactions between the hippocampus, prefrontal cortex, and amygdala support complex learning and memory

E Yavas, S Gonzalez, MS Fanselow - F1000Research, 2019 - ncbi.nlm.nih.gov
One of the guiding principles of memory research in the preceding decades is multiple
memory systems theory, which links specific task demands to specific anatomical structures …

The role of D-amino acids in Alzheimer's disease

L Piubelli, G Murtas, V Rabattoni… - Journal of Alzheimer's …, 2021 - content.iospress.com
Abstract Alzheimer's disease (AD), the main cause of dementia worldwide, is characterized
by a complex and multifactorial etiology. In large part, excitatory neurotransmission in the …

Biosensors for D-amino acids: detection methods and applications

E Rosini, P D'Antona, L Pollegioni - International Journal of Molecular …, 2020 - mdpi.com
D-enantiomers of amino acids (D-AAs) are only present in low amounts in nature, frequently
at trace levels, and for this reason, their biological function was undervalued for a long time …

d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia

YJ Cheng, CH Lin, HY Lane - International Journal of Molecular Sciences, 2021 - mdpi.com
Numerous studies over the last several years have shown that d-amino acids, especially d-
serine, have been related to brain and neurological disorders. Acknowledged neurological …

New evidence on the role of d-aspartate metabolism in regulating brain and endocrine system physiology: From preclinical observations to clinical applications

A Usiello, MM Di Fiore, A De Rosa, S Falvo… - International Journal of …, 2020 - mdpi.com
The endogenous amino acids serine and aspartate occur at high concentrations in free D-
form in mammalian organs, including the central nervous system and endocrine glands. D …

Neuroprotective activity of selenium nanoparticles against the effect of amino acid enantiomers in Alzheimer's disease

D Vicente-Zurdo, S Rodríguez-Blázquez… - Analytical and …, 2022 - Springer
Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease, is
characterized by extracellular accumulation of amyloid-beta protein (Aβ), which is believed …