Reactive oxygen species (ROS) play an important role in the pathogenesis of numerous
diseases including atherosclerosis, diabetes, inflammation and myocardial infarction (MI). In …

Cellular metabolism plays a major role in the regulation of inflammation. The inflammatory
macrophages undergo a wide‐range of metabolic rewriting due to the production of …

Originally designed as anti-hyperglycemic drugs, Glucagon-Like Peptide-1 receptor
agonists (GLP-1Ra) and Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have …

Robust activation of mTOR (mammalian target of rapamycin) signaling in diabetes
exacerbates myocardial injury following lethal ischemia due to accelerated cardiomyocyte …

Purpose Computational modelling may improve the fundamental understanding of various
mechanisms of diseases more particularly related to clinical challenges. In this study the …

Background: The recognition of RV overpressure is critical to human life, as this may signify
morbidity and mortality. Right ventricle (RV) dysfunction is understood to have an impact on …

The effect of myocardial infarction on the global functioning of the heart is well known. Less
is understood regarding the effect of LV fibrotic infarction on the cardiac mechanics of the …

The physiological basis of the right ventricle diastolic function is not well studied. In most
heart failure, heart transplantation remains the first choice with survival ranges between 40 …

Following the acute phase of a myocardial infarction, a set of structural and functional
changes evolves in the myocardium, collectively referred to as cardiac remodeling. This …

Background The sequelae of myocardial infarction (MI) require specific pharmacological
therapy to minimise the post-MI remodelling, which in many cases evolves into …