Microenvironment and radiation therapy

M Yoshimura, S Itasaka, H Harada… - BioMed research …, 2013 - Wiley Online Library
Dependency on tumor oxygenation is one of the major features of radiation therapy and this
has led many radiation biologists and oncologists to focus on tumor hypoxia. The first …

Targeting the DNA damage response in cancer

M Ljungman - Chemical reviews, 2009 - ACS Publications
US general Ulysses S. Grant once said:“The art of war is simple enough. Find out where
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision …

Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas

PH Gutin, FM Iwamoto, K Beal, NA Mohile… - International Journal of …, 2009 - Elsevier
PURPOSE: Preclinical studies suggest that inhibition of vascular endothelial growth factor
(VEGF) improves glioma response to radiotherapy. Bevacizumab, a monoclonal antibody …

Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells

GO Ahn, JM Brown - Cancer cell, 2008 - cell.com
Tumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone
marrow (BM)-derived circulating cells (vasculogenesis). By using a model system of …

Establishing the impact of vascular damage on tumor response to high-dose radiation therapy

KD Castle, DG Kirsch - Cancer research, 2019 - AACR
Approximately half of all patients with cancer receive radiotherapy, which is conventionally
delivered in relatively small doses (1.8–2 Gy) per daily fraction over one to two months …

Re-evaluating the risk factors for radiation pneumonitis in the era of immunotherapy

F Chen, J Niu, M Wang, H Zhu, Z Guo - Journal of Translational Medicine, 2023 - Springer
As one of the common complications of radiotherapy, radiation pneumonia (RP) limits the
prognosis of patients. Therefore, better identifying the high-risk factors that lead to RP is …

Effects of irradiation on tumor cell survival, invasion and angiogenesis

O Kargiotis, A Geka, JS Rao, AP Kyritsis - Journal of neuro-oncology, 2010 - Springer
Ionizing irradiation is a widely applied therapeutic method for the majority of solid malignant
neoplasms, including brain tumors where, depending on localization, this might often be the …

Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?

SV Kozin, DG Duda, LL Munn… - Journal of the National …, 2012 - academic.oup.com
Local relapse of tumors after radiation therapy remains a challenge in oncology. To devise
rational approaches for preventing this relapse, we have to improve our understanding of …

恩度联合化疗治疗中晚期非小细胞肺癌的疗效观察

蔡莉, 孙立春, 杨春雨, 孟庆威, 庞慧, 隋广杰 - 中国实用内科杂志, 2007 - cqvip.com
目的对恩度(新型重组人血管内皮抑素) 联合化疗和单纯化疗治疗中晚期非小细胞肺癌的疗效,
毒副反应进行比较. 方法将2006 年9 月至2007 年3 月哈尔滨医科大学附属肿瘤医院内科就诊的 …

Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance

G Multhoff, J Radons, P Vaupel - Cancers, 2014 - mdpi.com
Newly formed microvessels in most solid tumors show an abnormal morphology and thus do
not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and …