NRF2 and cancer: the good, the bad and the importance of context
MB Sporn, KT Liby - Nature Reviews Cancer, 2012 - nature.com
Many studies of chemopreventive drugs have suggested that their beneficial effects on
suppression of carcinogenesis and many other chronic diseases are mediated through …
suppression of carcinogenesis and many other chronic diseases are mediated through …
Diabetes, oxidative stress and therapeutic strategies
L Rochette, M Zeller, Y Cottin, C Vergely - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background Diabetes has emerged as a major threat to health worldwide. Scope of Review
The exact mechanisms underlying the disease are unknown; however, there is growing …
The exact mechanisms underlying the disease are unknown; however, there is growing …
Small molecule modulators of K eap1‐N rf2‐ARE pathway as potential preventive and therapeutic agents
S Magesh, Y Chen, L Hu - Medicinal research reviews, 2012 - Wiley Online Library
K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …
[HTML][HTML] Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy
Peripheral neuropathy is a severe dose limiting toxicity associated with cancer
chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying …
chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying …
[HTML][HTML] Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
M Matzinger, K Fischhuber, EH Heiss - Biotechnology advances, 2018 - Elsevier
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease
KT Liby, MB Sporn - Pharmacological reviews, 2012 - ASPET
We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from …
and treatment of disease, as well as extensive biological data on this topic resulting from …
Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein
D Béraud, HA Hathaway, J Trecki… - Journal of Neuroimmune …, 2013 - Springer
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder typified by tremor, rigidity, akinesia and postural instability due in part to the loss of …
disorder typified by tremor, rigidity, akinesia and postural instability due in part to the loss of …
Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes
High glucose driven reactive oxygen intermediates production and inflammatory damage
are recognized contributors of nerve dysfunction and subsequent damage in diabetic …
are recognized contributors of nerve dysfunction and subsequent damage in diabetic …
Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original …
J Carillon, JM Rouanet, JP Cristol, R Brion - Pharmaceutical research, 2013 - Springer
Oxidative stress, involved in many diseases, is defined as an impaired balance between
reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes …
reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes …
Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats
R Tian, W Yang, Q Xue, L Gao, J Huo, D Ren… - European journal of …, 2016 - Elsevier
Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin
an attractive candidate for diabetic complications. The present study was designed to …
an attractive candidate for diabetic complications. The present study was designed to …