Oncolytic viruses (OVs) are emerging as potentially useful platforms in treatment methods for
patients with tumors. They preferentially target and kill tumor cells, leaving healthy cells …

Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Interleukin-12 is considered a potent agent to enhance antitumor immune responses. It
belongs to a family of heterodimeric cytokines with key roles in the up-regulation and down …

During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent
cytokines in mediating antitumor activity in a variety of preclinical models. Through …

Combination therapy and nanotechnology offer a promising therapeutic method in cancer
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …

Cancer immunotherapy is now a powerful clinical reality, with a steady progression of new
drug approvals and a massive pipeline of additional treatments in clinical and preclinical …

It is a challenge to effectively reactivate preexisting tumor-infiltrating lymphocytes (TILs)
without causing severe toxicity. Interleukin-12 (IL-12) can potently activate lymphocytes, but …

Abstract CD4 help for CD8+ T lymphocytes prevents tolerance and promotes the survival of
effector and memory CD8+ T cells. Here, we describe additional helper functions that …

Chimaeric antigen receptor (CAR) T-cells are T-cells that have been genetically modified to
express an artificial construct consisting of a synthetic T-cell receptor (TCR) targeted to a …