Major review: Molecular genetics of primary open-angle glaucoma
Y Liu, RR Allingham - Experimental eye research, 2017 - Elsevier
Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …
glaucoma (POAG), the most common type, is a complex inherited disorder that is …
The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology
SF Janssen, TGMF Gorgels, WD Ramdas… - Progress in retinal and …, 2013 - Elsevier
Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …
triggered by both environmental and genetic risk factors. Several ocular tissues, including …
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1
We report a genome-wide association study for open-angle glaucoma (OAG) blindness
using a discovery cohort of 590 individuals with severe visual field loss (cases) and 3,956 …
using a discovery cohort of 590 individuals with severe visual field loss (cases) and 3,956 …
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
Central corneal thickness (CCT) is associated with eye conditions including keratoconus
and glaucoma. We performed a meta-analysis on> 20,000 individuals in European and …
and glaucoma. We performed a meta-analysis on> 20,000 individuals in European and …
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide.
We performed a genome-wide association study in an Australian discovery cohort …
We performed a genome-wide association study in an Australian discovery cohort …
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
We conducted a genome-wide association study for primary open-angle glaucoma (POAG)
in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a …
in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a …
Copy number variations on chromosome 12q14 in patients with normal tension glaucoma
JH Fingert, AL Robin, JL Stone, BR Roos… - Human molecular …, 2011 - academic.oup.com
We report identification of a novel genetic locus (GLC1P) for normal tension glaucoma
(NTG) on chromosome 12q14 using linkage studies of an African-American pedigree …
(NTG) on chromosome 12q14 using linkage studies of an African-American pedigree …
The intertwined roles of oxidative stress and endoplasmic reticulum stress in glaucoma
DJ Hurley, C Normile, M Irnaten, C O'Brien - Antioxidants, 2022 - mdpi.com
Glaucoma is the leading cause of irreversible blindness worldwide, and the burden of the
disease continues to grow as the global population ages. Currently, the only treatment …
disease continues to grow as the global population ages. Currently, the only treatment …
Common genetic variants associated with open-angle glaucoma
WD Ramdas, LME van Koolwijk… - Human molecular …, 2011 - academic.oup.com
Open-angle glaucoma (glaucoma) is a major eye disorder characterized by optic disc
pathology. Recent genome-wide association studies identified new loci associated with …
pathology. Recent genome-wide association studies identified new loci associated with …
Glaucoma: genes, phenotypes, and new directions for therapy
Glaucoma, a leading cause of blindness worldwide, is characterized by progressive optic
nerve damage, usually associated with intraocular pressure. Although the clinical …
nerve damage, usually associated with intraocular pressure. Although the clinical …