Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
RNA molecules can fold into intricate shapes that can provide an additional layer of control
of gene expression beyond that of their sequence. In this Review, we discuss the current …
of gene expression beyond that of their sequence. In this Review, we discuss the current …
RNA methyltransferase METTL16: Targets and function
ER Satterwhite, KD Mansfield - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
Abstract The N6‐methyladenosine (m6A) RNA methyltransferase METTL16 is an emerging
player in the RNA modification landscape of the human cell. Originally thought to be a …
player in the RNA modification landscape of the human cell. Originally thought to be a …
The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for
a wide variety of biological processes. We demonstrate that the N 6-adenosine …
a wide variety of biological processes. We demonstrate that the N 6-adenosine …
S-Adenosylmethionine synthesis is regulated by selective N6-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1
H Shima, M Matsumoto, Y Ishigami, M Ebina, A Muto… - Cell reports, 2017 - cell.com
S-adenosylmethionine (SAM) is an important metabolite as a methyl-group donor in DNA
and histone methylation, tuning regulation of gene expression. Appropriate intracellular …
and histone methylation, tuning regulation of gene expression. Appropriate intracellular …
RNA–protein interaction detection in living cells
RNA–protein interactions play numerous roles in cellular function and disease. Here we
describe RNA–protein interaction detection (RaPID), which uses proximity-dependent …
describe RNA–protein interaction detection (RaPID), which uses proximity-dependent …
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
JE Squires, HR Patel, M Nousch, T Sibbritt… - Nucleic acids …, 2012 - academic.oup.com
The modified base 5-methylcytosine (m 5 C) is well studied in DNA, but investigations of its
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …
A high-resolution map of human evolutionary constraint using 29 mammals
The comparison of related genomes has emerged as a powerful lens for genome
interpretation. Here we report the sequencing and comparative analysis of 29 eutherian …
interpretation. Here we report the sequencing and comparative analysis of 29 eutherian …
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease
IA Qureshi, MF Mehler - Nature Reviews Neuroscience, 2012 - nature.com
Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a
rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture …
rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture …
Structural basis for regulation of METTL16, an S-adenosylmethionine homeostasis factor
KA Doxtader, P Wang, AM Scarborough, D Seo… - Molecular cell, 2018 - cell.com
S-adenosylmethionine (SAM) is an essential metabolite that acts as a cofactor for most
methylation events in the cell. The N 6-methyladenosine (m 6 A) methyltransferase …
methylation events in the cell. The N 6-methyladenosine (m 6 A) methyltransferase …
Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
A Kapusta, C Feschotte - Trends in Genetics, 2014 - cell.com
Thousands of genes encoding long noncoding RNAs (lncRNAs) have been identified in all
vertebrate genomes thus far examined. The list of lncRNAs partaking in arguably important …
vertebrate genomes thus far examined. The list of lncRNAs partaking in arguably important …