There is an ongoing shift in demographics such that older persons will outnumber young
persons in the coming years, and with it age-associated tissue attrition and increased …

Purpose Terrorist use of nuclear weapons and radiation accidents put the human population
at risk for exposure to life-threatening levels of radiation. Victims of lethal radiation exposure …

The hematopoietic system is highly sensitive to stress from both aging and radiation
exposure, and the hematopoietic acute radiation syndrome (H-ARS) should be modeled in …

The goal of this study was to develop rat models of partial body irradiation with bone-marrow
sparing (leg-out PBI) to test medical countermeasures (MCM) of both acute radiation …

Introduction: In experimental animal models, biological sex-differences in the manifestation
and severity of normal tissue radiation injury have been well-documented. Previously we …

Abstract Development of medical countermeasures against radiation relies on robust animal
models for efficacy testing. Mouse models have advantages over larger species due to …

Lymphoid lineage recovery and involution after exposure to potentially lethal doses of
ionizing radiation have not been well defined, especially the long-term effects in aged …

Exposure to potentially lethal high-dose ionizing radiation results in bone marrow
suppression, known as the hematopoietic acute radiation syndrome (H-ARS), which can …

Medical countermeasures (MCMs) for hematopoietic acute radiation syndrome (H-ARS)
should be evaluated in well-characterized animal models, with consideration of at-risk …

The hematopoietic system is highly sensitive to ionizing radiation. Damage to the immune
system may result in opportunistic infections and hemorrhage, which could lead to mortality …