Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R)
agonists, cause aversive responses such as nausea and vomiting,, effects that may …

The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

The parabrachial nucleus (PBN), which is located in the pons and is dissected by one of the
major cerebellar output tracks, is known to relay sensory information (visceral malaise, taste …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Food intake is tightly regulated by complex and coordinated gut-brain interactions. Nutrients
rapidly modulate activity in key populations of hypothalamic neurons that regulate food …

Animals must set behavioural priority in a context-dependent manner and switch from one
behaviour to another at the appropriate moment,–. Here we probe the molecular and …

The parabrachial nucleus (PBN) has long been recognized as a sensory relay receiving an
array of interoceptive and exteroceptive inputs relevant to taste and ingestive behavior, pain …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …