Cisplatin is a widely used chemotherapy agent in the treatment of various forms of
carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients …

Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …

Background. Platinum-based anticancer drugs are widely used in the chemotherapy of
human neoplasms. The major obstacle for the clinical use of this class of drugs is the …

The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The body is equipped with broad-specificity transporters for the excretion and distribution of
endogeneous organic cations and for the uptake, elimination and distribution of cationic …

The use of the effective antineoplastic agent cisplatin is limited by its serious side effects,
such as oto-and nephrotoxicity. Ototoxicity is a problem of special importance in children …