Exposure to stress during early development may lead to altered neurobiological functions,
thus increasing the risk for psychiatric illnesses later in life. One potential mechanism …

Stressful life experiences are associated with the development of neuropsychiatric disorders
like depression. Emerging evidence indicates that microglia, the specialized resident …

Perineuronal nets (PNNs) are a condensed subtype of extracellular matrix that form a net-
like coverings around certain neurons in the brain. PNNs are primarily composed of …

Background A comprehensive picture is lacking of the impact of early childhood (age 0–5)
risk factors on the subsequent development of mental health symptoms. Objective In this …

Alzheimer's disease (AD) is prevalent around the world, yet our understanding of the
disease is still very limited. Recent work suggests that the cornerstone of AD may include the …

Microglia are the immune cell in the central nervous system (CNS) and exist in a surveillant
state characterized by a ramified form in the healthy brain. In response to brain injury or …

Microglia play numerous important roles in brain development. From early embryonic stages
through adolescence, these immune cells influence neuronal genesis and maturation, guide …

Exposure to adversities during early life stages (early life adversities-ELA), ranging from
pregnancy to adolescence, represents a major risk factor for the vulnerability to mental …

The olfactory bulb (OB), a major structure of the limbic system, has been understudied in
human investigations of psychopathologies such as depression. To explore more directly …

Adverse early life experiences are strongly associated with reduced cognitive function
throughout life. The link is strong in many human studies, but these do not enable assigning …