Brain plasticity is dynamically regulated across the life span, peaking during windows of
early life. Typically assessed in the physiological range of milliseconds (real time), these …

Early life stress–including experience of child maltreatment, neglect, separation from or loss
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …

Perineuronal nets (PNNs) surrounding fast-spiking, parvalbumin (PV) interneurons provide
excitatory: inhibitory balance, which is impaired in several disorders associated with altered …

Fast-spiking parvalbumin interneurons are critical for the function of mature cortical inhibitory
circuits. Most of these neurons are enwrapped by a specialized extracellular matrix (ECM) …

Choroid plexus (ChP), a vascularized secretory epithelium located in all brain ventricles,
plays critical roles in development, homeostasis and brain repair. Reverse transcription …

In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for
cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate …

The homeodomain is found in hundreds of transcription factors that play roles in fate
determination via cell-autonomous regulation of gene expression. However, some …