Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically …

The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Ferroptosis is a recently discovered essential type of cell death that is mainly characterized
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …

Significance: Autophagy is a self-degrading process that determines cell fate in response to
various environmental stresses. In contrast to autophagy-mediated cell survival, the signals …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal
and lysosomal compartments. It is involved in the turnover of intracellular and extracellular …

In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the
younger population. Effective treatment is crucial for improving patients' survival outcomes …

Cross-talk between the tumor microenvironment (TME) and cancer cells plays an important
role in acquired drug resistance to epidermal growth factor receptor tyrosine kinase …

Ferroptosis is a form of regulated cell death that is initiated by excessive lipid peroxidation
that results in plasma membrane damage and the release of damage-associated molecular …

Cancer stem cells (CSCs) are promising targets for improving anticancer treatment
outcomes while eliminating recurrence, but their treatment remains a major challenge. Here …