[HTML][HTML] DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer
DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …
Novel diagnostic biomarkers in colorectal cancer
AL Zygulska, P Pierzchalski - International journal of molecular sciences, 2022 - mdpi.com
Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …
Epigenetic alterations in colorectal cancer: emerging biomarkers
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …
fundamental processes driving the initiation and progression of CRC is the accumulation of …
Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics
In the past decade, there have been fundamental advances in our understanding of genetic
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …
Cancer epigenetics
PW Laird - Human molecular genetics, 2005 - academic.oup.com
The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …
understanding of chromatin structure, histone modification, transcriptional activity and DNA …
DNA methylation markers in colorectal cancer
MS Kim, J Lee, D Sidransky - Cancer and Metastasis Reviews, 2010 - Springer
Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …
Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer
JMK Ng, J Yu - International journal of molecular sciences, 2015 - mdpi.com
Colorectal cancer (CRC) is a common malignancy and the fourth leading cause of cancer
deaths worldwide. It results from the accumulation of multiple genetic and epigenetic …
deaths worldwide. It results from the accumulation of multiple genetic and epigenetic …
Serrated neoplasia—role in colorectal carcinogenesis and clinical implications
Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …
Colorectal cancer screening: prospects for molecular stool analysis
Colorectal cancer is common. As many patients present with advanced disease, an effective
screening test would have substantial clinical benefits. Recent progress in understanding …
screening test would have substantial clinical benefits. Recent progress in understanding …
Detection in fecal DNA of colon cancer–specific methylation of the nonexpressed vimentin gene
WD Chen, ZJ Han, J Skoletsky, J Olson… - Journal of the …, 2005 - academic.oup.com
Background: Increased DNA methylation is an epigenetic alteration that is common in
human cancers and is often associated with transcriptional silencing. Aberrantly methylated …
human cancers and is often associated with transcriptional silencing. Aberrantly methylated …