Although conventionally associated with fibrin clot degradation, recent work has uncovered
new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central …

The extracellular matrix (ECM) plays diverse roles in several physiological and pathological
conditions. In the brain, the ECM is unique both in its composition and in functions …

Long-term memory is thought to be mediated by protein synthesis–dependent, late-phase
long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) …

Sensory experience physically rewires the brain in early postnatal life through unknown
processes. Here, we identify a robust anatomical consequence of monocular deprivation …

Repeated stress can impair function in the hippocampus, a brain structure essential for
learning and memory. Although behavioral evidence suggests that severe stress triggers …

Astrocytes express a wide range of G‐protein coupled receptors that trigger release of
intracellular Ca2+, including P2Y, bradykinin and protease activated receptors (PARs). By …

For over a decade, tissue-type plasminogen activator (t-PA), a serine protease classically
known for its profibrinolytic role in the vasculature, has been implicated in numerous aspects …

Exercise has been shown to impact brain plasticity and function by involving the action of
brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly …

Activation of glucocorticoid receptors (GR) by glucocorticoid hormones (GC) enhances
contextual fear memories through the activation of the Erk1/2 MAPK signaling pathway …

The excitatory neurotransmission of the central nervous system (CNS) mainly involves
glutamate and its receptors, especially N-methyl-D-Aspartate receptors (NMDARs). These …