A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning

LP Fang, Q Liu, E Meyer, A Welle, W Huang, A Scheller… - Glia, 2023 - Wiley Online Library
Oligodendrocyte precursor cells (OPCs) are uniformly distributed in the mammalian brain;
however, their function is rather heterogeneous in respect to their origin, location …

Multiple sclerosis and the endogenous opioid system

Z Dworsky-Fried, CI Chadwick, BJ Kerr… - Frontiers in …, 2021 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation,
neuronal degeneration and demyelinating lesions within the central nervous system. The …

[HTML][HTML] Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives

M García-Domínguez - Biomolecules, 2024 - pmc.ncbi.nlm.nih.gov
Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain
modulation. Enkephalins primarily exert their effects through opioid receptors located widely …

Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice

A Tanaka, K Anada, M Yasue, T Honda, H Nakamura… - Life Sciences, 2022 - Elsevier
Abstract Changes in sphingolipid metabolism regulate and/or alter many cellular functions in
the brain. Ceramide, a central molecule of sphingolipid metabolism, is phosphorylated to …

Electroacupuncture at ST36 acupoint regulates stem cells during experimental autoimmune encephalomyelitis

X Chen, Y Wang, J Ji, C Li, W Zhuang, J Luo… - International …, 2023 - Elsevier
Background Electroacupuncture (EA) is given to assist in the treatment of MS, which is an
effective therapeutic method. However, the therapy mechanism of EA related to stem cells in …

Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis

C Patel, IS Zagon, M Pearce‐Clawson… - Journal of …, 2022 - Wiley Online Library
Multiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that
primarily affects women during the second or third decade of life. The mechanism is …

[图书][B] Clinical and Morphological Manifestations of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis Resulting from Modulation of Endogenous …

CL Patel - 2021 - search.proquest.com
Multiple Sclerosis (MS) is an autoimmune, progressive demyelinating disorder specific to the
central nervous system initially described in 1868 by Jean-Martin Charcot. Initial accounts of …