Chaperones have long been recognized to play well defined functions such as to:(i) assist
protein folding and promote formation and maintenance of multisubunit complexes;(ii) …

Aggregation of the amyloid β protein (Aβ) peptide with 40 or 42 residues is one key feature
in Alzheimer's disease (AD). The 1, 4-naphthoquinon-2-yl-l-tryptophan (NQTrp) molecule …

Conformational diseases represent a new aspect of proteomic medicine where diagnostic
and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell …

The self-assembly of the amyloid-β (Aβ) peptide of various amino acid lengths into senile
plaques is one hallmark of Alzheimer's disease pathology. In the past decade, many small …

Objectives We explored the underlying mechanisms that facilitate reducing and enhancing
effects of exogenous proteins on cytotoxicity of amyloid β (Aβ), a main pathogen of …

β-Amyloid (Aβ) is a hallmark peptide of Alzheimer's disease (AD). Herein, we explored the
mechanism underlying the cytotoxicity of this peptide. Double treatment with oligomeric 42 …

Background This study was designed to evaluate the free radical scavenging property of
chloroform extract of the bark of Stereospermum chelonoides (SCBC) and to investigate its …

Background: This study was designed to evaluate the free radical scavenging property of
chloroform extract of the bark of Stereospermum chelonoides (SCBC) and to investigate its …

Objectives We explored the underlying mechanisms that facilitate reducing and enhancing
effects of exogenous proteins on cytotoxicity of amyloid b (Ab), a main pathogen of …

Alzheimer's disease is a devastating neurodegenerative disease clearly characterized by
loss of synapses, changes in metabolism, and neuronal death in brain tissue. The impact of …