SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …

Nutrient signaling through insulin/IGF-1 was the first pathway demonstrated to regulate
ageing and age-related disease in model organisms. Pharmacological or dietary …

Thyroid-associated ophthalmopathy (TAO) is a vexing and poorly understood autoimmune
process involving the upper face and tissues surrounding the eyes. In TAO, the orbit can …

Cardiovascular disease and cancer are 2 of the largest contributors to death in the United
States. Currently, there are more than 15 million individuals with a history of cardiovascular …

Sevoflurane is a new type of inhalation anesthetic used widely in the clinic. It has the
characteristics of rapid induction, rapid recovery, and less irritative to the airway. Studies …

The signaling pathways of interleukin-6 (IL-6) and insulin-like growth factor 1 (IGF-1) play an
important role in the progression of lung cancer, and this study aimed to explore whether …

Objective We explored the role of insulin-like growth factor 1 (igf-1) in the development of
lung cancer. Methods We used immunohistochemistry to measure the expression of igf-1 …

A series of novel 2-amino-4-pyrazolecyclopentylpyrimidines have been prepared and
evaluated as IGF-1R tyrosin kinase inhibitors. The in vitro activity was found to depend …

Cervical cancer is among the most frequently occurring neoplasms worldwide, and it
particularly affects individuals in developing countries. Factors such as the low quality of …

The aim of the present study was to investigate the expression and clinical significance of
oncofetal protein insulin-like growth factor (IGF) II mRNA-binding protein 3 (IMP3) in the …