Oleanolic acid: extraction, characterization and biological activity

JM Castellano, S Ramos-Romero, JS Perona - Nutrients, 2022 - mdpi.com
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is
receiving outstanding attention from the scientific community due to its biological activity …

Early-life origins of metabolic syndrome: mechanisms and preventive aspects

CN Hsu, CY Hou, WH Hsu, YL Tain - International journal of molecular …, 2021 - mdpi.com
One of the leading global public-health burdens is metabolic syndrome (MetS), despite the
many advances in pharmacotherapies. MetS, now known as “developmental origins of …

Research progress of coumarins and their derivatives in the treatment of diabetes

Y Pan, T Liu, X Wang, J Sun - Journal of Enzyme Inhibition and …, 2022 - Taylor & Francis
Diabetes is a group of metabolic diseases characterised by chronic hyperglycaemia caused
by multiple causes, which is caused by insulin secretion and/or utilisation defects. It is …

Recent advances in medicinal chemistry of oleanolic acid derivatives

YH Yang, SY Dai, FH Deng, LH Peng, C Li, YH Pei - Phytochemistry, 2022 - Elsevier
Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible
and medicinal plants, exhibits a wide spectrum of pharmacological activities and …

[HTML][HTML] Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases

A Sen - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally
effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles …

[HTML][HTML] Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD: A promising drug Potentilla discolor Bunge

L Ji, Q Li, Y He, X Zhang, Z Zhou, Y Gao, M Fang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of
hepatic lipids and metabolic stress-induced liver injury. There are currently no approved …

[HTML][HTML] Pentacyclic triterpene oleanolic acid protects against cardiac aging through regulation of mitophagy and mitochondrial integrity

Y Gong, Y Luo, S Liu, J Ma, F Liu, Y Fang, F Cao… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Advanced aging exhibits altered cardiac geometry and function involving mitochondrial
anomaly. Natural compounds display promises in the regulation of cardiac homeostasis via …

Oleanolic acid improves obesity-related inflammation and insulin resistance by regulating macrophages activation

W Li, H Zeng, M Xu, C Huang, L Tao, J Li… - Frontiers in …, 2021 - frontiersin.org
The chronic low-grade inflammation of adipose tissues, primarily mediated by adipose
tissue macrophages (ATMs), is the key pathogenic link between obesity and metabolic …

Molecular mechanisms underlying the effects of olive oil triterpenic acids in obesity and related diseases

CM Claro-Cala, F Jiménez-Altayó, S Zagmutt… - Nutrients, 2022 - mdpi.com
Dietary components exert protective effects against obesity and related metabolic and
cardiovascular disturbances by interfering with the molecular pathways leading to these …

Potential molecular targets of oleanolic acid in insulin resistance and underlying oxidative stress: a systematic review

A Fernandez-Aparicio, M Correa-Rodriguez… - Antioxidants, 2022 - mdpi.com
Oleanolic acid (OA) is a natural triterpene widely found in olive leaves that possesses
antioxidant, anti-inflammatory, and insulin-sensitizing properties, among others. These OA …