Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be
obtained from daily food intake or synthesized in the body through the urea cycle using l …

Increased protein citrullination is linked to various diseases including rheumatoid arthritis
(RA), lupus, and cancer. Citrullinated autoantigens, a hallmark of RA, are recognized by anti …

The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …

Protein arginine deimination leading to the non-coded amino acid citrulline remains a key
question in the field of post-translational modifications ever since its discovery by Rogers …

Peptidylarginine deiminases (PADs) catalyze the conversion of arginine residues to
citrulline residues on target proteins in the presence of calcium ions. This elaborate type of …

Post-translational modifications (PTMs) of proteins are central to epigenetic regulation and
cellular signalling, playing an important role in the pathogenesis and progression of …

Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the
breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis. This reaction is …

Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …

The post-translational modification of key residues at the C-terminal domain of RNA
polymerase II (RNAP2-CTD) coordinates transcription, splicing, and RNA processing by …