Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain.
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …

Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in
Alzheimer's disease (AD). However, the mechanism of synaptic damage remains …

Transient information input to the brain leads to persistent changes in synaptic circuits,
contributing to the formation of memory engrams. Pre-and postsynaptic structures undergo …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Structure, Function, and Pharmacology of NMDA Receptor Channels Page 1
PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2014 …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

The peak concentration and rate of clearance of neurotransmitter from the synaptic cleft are
important determinants of synaptic function, yet the neurotransmitter concentration time …

Fast excitatory neurotransmission is mediated by activation of synaptic ionotropic glutamate
receptors. In hippocampal slices, we report that stimulation of Schaffer collaterals evokes in …