International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
Serotonin receptors in depression and anxiety: Insights from animal studies
Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …
The neurobiology and control of anxious states
MJ Millan - Progress in neurobiology, 2003 - Elsevier
Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
The primary cilium as a cellular receiver: organizing ciliary GPCR signaling
KI Hilgendorf, CT Johnson, PK Jackson - Current opinion in cell biology, 2016 - Elsevier
The primary cilium is an antenna-like cellular protrusion mediating sensory and
neuroendocrine signaling. Its localization within tissue architecture and a growing list of cilia …
neuroendocrine signaling. Its localization within tissue architecture and a growing list of cilia …
Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia
NF Berbari, JS Lewis, GA Bishop… - Proceedings of the …, 2008 - National Acad Sciences
Primary cilia are ubiquitous cellular appendages that provide important yet not well
understood sensory and signaling functions. Ciliary dysfunction underlies numerous human …
understood sensory and signaling functions. Ciliary dysfunction underlies numerous human …
Ins and outs of GPCR signaling in primary cilia
Primary cilia are specialized microtubule‐based signaling organelles that convey
extracellular signals into a cellular response in most vertebrate cell types. The physiological …
extracellular signals into a cellular response in most vertebrate cell types. The physiological …
Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors
NF Berbari, AD Johnson, JS Lewis… - Molecular biology of …, 2008 - Am Soc Cell Biol
Primary cilia are sensory organelles present on most mammalian cells. The functions of cilia
are defined by the signaling proteins localized to the ciliary membrane. Certain G protein …
are defined by the signaling proteins localized to the ciliary membrane. Certain G protein …
[HTML][HTML] Serotonin receptors in depression: from A to B
KM Nautiyal, R Hen - F1000Research, 2017 - ncbi.nlm.nih.gov
The role of serotonin in major depressive disorder (MDD) is the focus of accumulating
clinical and preclinical research. The results of these studies reflect the complexity of …
clinical and preclinical research. The results of these studies reflect the complexity of …
Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain
GA Bishop, NF Berbari, J Lewis… - Journal of Comparative …, 2007 - Wiley Online Library
Solitary primary cilia project from nearly every cell type in the human body. These organelles
are considered to have important sensory and signaling functions. Although primary cilia …
are considered to have important sensory and signaling functions. Although primary cilia …
5-ht6 receptors
ML Woolley, CA Marsden… - Current Drug Targets-CNS …, 2004 - ingentaconnect.com
The 5-hydroxytryptamine6 (5-ht6) was one of the most recent additions to the5-HT receptor
family, selective antagonists have recently been developed and potentialfunctional roles are …
family, selective antagonists have recently been developed and potentialfunctional roles are …