Vascular and haemodynamic issues of brain ageing

L Beishon, RH Clough, M Kadicheeni… - … -European Journal of …, 2021 - Springer
The population is ageing worldwide, thus increasing the burden of common age-related
disorders to the individual, society and economy. Cerebrovascular diseases (stroke …

Cerebral autoregulation in ischemic stroke: from pathophysiology to clinical concepts

RC Nogueira, L Beishon, E Bor-Seng-Shu, RB Panerai… - Brain sciences, 2021 - mdpi.com
Ischemic stroke (IS) is one of the most impacting diseases in the world. In the last decades,
new therapies have been introduced to improve outcomes after IS, most of them aiming for …

Neurovascular coupling on trial: How the number of trials completed impacts the accuracy and precision of temporally derived neurovascular coupling estimates

JS Burma, RK Van Roessel, IK Oni… - Journal of Cerebral …, 2022 - journals.sagepub.com
Standard practices for quantifying neurovascular coupling (NVC) with transcranial Doppler
ultrasound (TCD) require participants to complete one-to-ten repetitive trials. However …

Cerebrovascular responses to somatomotor stimulation in Parkinson's disease: A multivariate analysis

SC Barnes, RB Panerai, L Beishon… - Journal of Cerebral …, 2022 - journals.sagepub.com
Parkinson's disease (PD) is a common neurodegenerative disorder, yet little is known about
cerebral haemodynamics in this patient population. Previous studies assessing dynamic …

Neurovascular coupling response to cognitive examination in healthy controls: a multivariate analysis

L Beishon, CAL Williams, TG Robinson… - Physiological …, 2018 - Wiley Online Library
Cognitive testing with transcranial Doppler ultrasonography (TCD) has been used to assess
neurovascular coupling (NVC), but few studies address its multiple contributions …

The effect of CO2 on the age dependence of neurovascular coupling

A Davies, D Gurung… - Journal of Applied …, 2024 - journals.physiology.org
Prior studies have identified variable effects of aging on neurovascular coupling (NVC).
Carbon dioxide (CO2) affects both cerebral blood velocity (CBv) and NVC, but the effects of …

The scalability of common paradigms for assessment of cognitive function: A functional transcranial Doppler study

K Intharakham, RB Panerai, TG Robinson - Plos one, 2022 - journals.plos.org
Cognitive paradigms induce changes in cerebral blood flow (CBF) associated with
increased metabolic demand, namely neurovascular coupling (NVC). We tested the …

Cognitive activity significantly affects the dynamic cerebral autoregulation, but not the dynamic vasoreactivity, in healthy adults

JM Rizko, LC Beishon, RB Panerai… - Frontiers in …, 2024 - frontiersin.org
Introduction Neurovascular coupling (NVC) is an important mechanism for the regulation of
cerebral perfusion during intensive cognitive activity. Thus, it should be examined in terms of …

[HTML][HTML] Challenging neurovascular coupling through complex and variable duration cognitive paradigms: A subcomponent analysis

K Ladthavorlaphatt, FBS Surti, LC Beishon… - Medical Engineering & …, 2022 - Elsevier
A similar pattern of cerebral blood velocity (CBv) response has been observed for
neurovascular coupling (NVC) assessment with cognitive tasks of varying complexity and …

Statistical Complexity Analysis of Neurovascular Coupling with Cognitive Stimulation in Healthy Subjects

H Rojas-Pescio, L Beishon, R Panerai… - Journal of Cognitive …, 2024 - direct.mit.edu
Neurovascular coupling (NVC) is the tight relationship between changes in cerebral blood
flow and neural activation. NVC can be evaluated non-invasively using transcranial Doppler …