Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Salivary glands sustain collateral damage following radiotherapy (RT) to treat cancers of the
head and neck, leading to complications, including mucositis, xerostomia and …

Background The most manifest long-term consequences of radiation therapy in the head
and neck cancer patient are salivary gland hypofunction and a sensation of oral dryness …

Understanding the dynamic transcriptional landscape throughout organ development will
provide a template for regenerative therapies. Here, we generated a single-cell RNA …

The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive.
Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin …

Current saliva-based stimulation therapies for radiotherapy-induced xerostomia are not fully
effective due to the presence of damaged secretory epithelia and nerves in the salivary …

Radiation therapy for head and neck cancers causes salivary gland dysfunction leading to
permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is …

Salivary gland hypofunction causes significant morbidity and loss of quality of life for head
and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet …

Nerves not only regulate the homeostasis and energetic metabolism of normal epithelial
cells but also are critical for cancer, as cancer recapitulates the biology of neural regulation …

Xerostomia or dry mouth are commonly diagnosed in head and neck cancer patients due to
salivary gland (SG) epithelial injury after radiotherapy. Regenerative medicine has fetched …