Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Fracture risk reduction and safety by osteoporosis treatment compared with placebo or active comparator in postmenopausal women: systematic review, network meta …

MN Händel, I Cardoso, C Von Bülow, JF Rohde… - bmj, 2023 - bmj.com
Objective To review the comparative effectiveness of osteoporosis treatments, including the
bone anabolic agents, abaloparatide and romosozumab, on reducing the risk of fractures in …

[HTML][HTML] Romosozumab and antiresorptive treatment: the importance of treatment sequence

F Cosman, DL Kendler, BL Langdahl, BZ Leder… - Osteoporosis …, 2022 - Springer
To evaluate whether treatment sequence affects romosozumab response, this analysis
reviewed studies where romosozumab was administered before or following an …

[HTML][HTML] The roles of circRNA–miRNA–mRNA networks in the development and treatment of osteoporosis

M Gao, Z Zhang, J Sun, B Li, Y Li - Frontiers in endocrinology, 2022 - frontiersin.org
Osteoporosis is a systemic metabolic disease, mainly characterized by reduced bone
mineral density and destruction of bone tissue microstructure. However, the molecular …

Curcumin delivery using tetrahedral framework nucleic acids enhances bone regeneration in osteoporotic rats

L Bai, M Feng, Q Li, Y Zhao, G Zhang, Z Cai… - Chemical Engineering …, 2023 - Elsevier
Osteoporosis is an age-related disorder characterized by progressive bone loss and
impaired bone regeneration following surgery. The key to the treatment of osteoporosis is …

Targeting the gut microbiota-related metabolites for osteoporosis: the inextricable connection of gut-bone axis

YW Zhang, Y Wu, XF Liu, X Chen, JC Su - Ageing research reviews, 2024 - Elsevier
Osteoporosis is a systemic skeletal disease characterized by decreased bone mass,
destruction of bone microstructure, raised bone fragility, and enhanced risk of fractures. The …

[HTML][HTML] Advancement in the treatment of osteoporosis and the effects on bone healing

Y Kushchayeva, I Pestun, S Kushchayev… - Journal of Clinical …, 2022 - mdpi.com
Osteoporosis (OP) is a major global health concern, with aging being one of the most
important risk factors. Osteoarthritis (OA) is also an age-related disorder. Patients with OP …

Romosozumab for the treatment of osteoporosis in women: Efficacy, safety, and cardiovascular risk

SY Lim - Women's Health, 2022 - journals.sagepub.com
Increased understanding of the Wnt signaling pathway has led to the development of
romosozumab, one of the most potent osteoanabolic agents to date for osteoporosis …

The role of osteoanabolic agents in the management of patients with osteoporosis

MR McClung, MS Rothman, EM Lewiecki… - Postgraduate …, 2022 - Taylor & Francis
Reducing fracture risk is the objective of osteoporosis treatment. Bone-forming osteoporosis
drugs increase bone mass, restore bone microarchitecture, and reduce fracture risk more …

Bone fragility: conceptual framework, therapeutic implications, and COVID-19-related issues

G Iolascon, M Paoletta, S Liguori… - Therapeutic …, 2022 - journals.sagepub.com
Bone fragility is the susceptibility to fracture even for common loads because of structural,
architectural, or material alterations of bone tissue that result in poor bone strength. In …