The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus
kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription …

Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen
infections by controlling inflammation and immune response by directly inducing anti …

Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal
transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine …

Cells maintain the balance between homeostasis and inflammation by adapting and
integrating the activity of intracellular signaling cascades, including the JAK-STAT pathway …

Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to
tailor these alterations in gene expression to the requirements of the inflammatory process …

Interferon-stimulated genes (ISGs) are a group of gene products that coordinately combat
pathogen invasions, in particular viral infections. Transcription of ISGs occurs rapidly upon …

Abstract Interferon gamma (IFN-γ), is a cytokine, which is an important regulator of host
defense system by mediating both innate and adaptive immune responses. IFN-γ signaling …

Background Pancreatic cancer is poorly characterized at genetic and non-genetic levels.
The current study evaluates in a large cohort of patients the prognostic relevance of …