Olfactory immunology: the missing piece in airway and CNS defence

SA Wellford, EA Moseman - Nature Reviews Immunology, 2024 - nature.com
The olfactory mucosa is a component of the nasal airway that mediates the sense of smell.
Recent studies point to an important role for the olfactory mucosa as a barrier to both …

Neuroinflammation in neurodegeneration via microbial infections

VTA Tran, LP Lee, H Cho - Frontiers in Immunology, 2022 - frontiersin.org
Recent epidemiological studies show a noticeable correlation between chronic microbial
infections and neurological disorders. However, the underlying mechanisms are still not …

Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer's disease risk

A Chacko, A Delbaz, H Walkden, S Basu… - Scientific reports, 2022 - nature.com
Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central
nervous system (CNS). Recently, the link between C. pneumoniae CNS infection and late …

Differences in gut microbiota correlate with symptoms and regional brain volumes in patients with late-life depression

CF Tsai, CH Chuang, YP Wang, YB Lin… - Frontiers in Aging …, 2022 - frontiersin.org
Depression is associated with gut dysbiosis that disrupts a gut-brain bidirectional axis. Gray
matter volume changes in cortical and subcortical structures, including prefrontal regions …

Phagocytosis by peripheral glia: Importance for nervous system functions and implications in injury and disease

L Nazareth, J St John, M Murtaza… - Frontiers in Cell and …, 2021 - frontiersin.org
The central nervous system (CNS) has very limited capacity to regenerate after traumatic
injury or disease. In contrast, the peripheral nervous system (PNS) has far greater capacity …

Multinucleated giant cell formation as a portal to chronic bacterial infections

JL Stockton, AG Torres - Microorganisms, 2020 - mdpi.com
This review provides a snapshot of chronic bacterial infections through the lens of
Burkholderia pseudomallei and detailing its ability to establish multi-nucleated giant cells …

In Vitro Roles of Burkholderia Intracellular Motility A (BimA) in Infection of Human Neuroblastoma Cell Line

N Jitprasutwit, A Rungruengkitkun… - Microbiology …, 2023 - Am Soc Microbiol
The bacterial pathogen Burkholderia pseudomallei causes human melioidosis, which can
infect the brain, leading to encephalitis and brain abscesses. Infection of the nervous system …

Cycle-Inhibiting Factor Is Associated with Burkholderia pseudomallei Invasion in Human Neuronal Cells

A Rungruengkitkun, N Jitprasutwit, W Muangkaew… - Biology, 2022 - mdpi.com
Simple Summary Neurological melioidosis, caused by Burkholderia pseudomallei, can lead
to the development of severe symptoms associated with the nervous system. However, the …

[HTML][HTML] Virulence of Burkholderia pseudomallei ATS2021 Unintentionally Imported to United States in Aromatherapy Spray

CK Cote, KD Mlynek, CP Klimko… - Emerging Infectious …, 2024 - pmc.ncbi.nlm.nih.gov
In the United States in 2021, an outbreak of 4 cases of Burkholderia pseudomallei, the
etiologic agent of melioidosis and a Tier One Select Agent (potential for deliberate misuse …

Type VI Secretion System Accessory Protein TagAB-5 Promotes Burkholderia pseudomallei Pathogenicity in Human Microglia

S Lohitthai, A Rungruengkitkun, N Jitprasutwit… - Biomedicines, 2023 - mdpi.com
Central nervous system (CNS) melioidosis caused by Burkholderia pseudomallei is being
increasingly reported. Because of the high mortality associated with CNS melioidosis …