Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Antibiotic resistance is a significant emerging health threat. Exacerbating this problem is the
overprescription of antibiotics as well as a lack of development of new antibacterial agents …

In this work, a novel nanocomposite film consisting of the Au nanoparticles/graphene-
chitosan has been designed to construct an impedimetric immunosensor for a rapid and …

Amino-pyrazoles have proven to be a class of fascinating and privileged organic tools for the
construction of diverse heterocyclic or fused heterocyclic scaffolds. This review presents …

An integrated strategy that combined in silico screening and tiered biochemical assays
(enzymatic, in vitro, and ex vivo) was used to identify and characterize effective small …

Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as
category A biothreat agents by the US CDC. The BoNT-mediated proteolysis of SNARE …

Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease
known as botulism that could afflict large, unprotected populations if the toxin were …

Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease
known as botulism. Current treatment for post exposure of BoNTA uses antibodies that are …

A series of novel 7-aminoalkyl substituted pyrazolo [1, 5-a] pyrimidine derivatives were
synthesized and tested for inhibition of cathepsin K. The synthetic methodology comprises …

Botulinum neurotoxins (BoNTs), a family of proteins produced by the bacterium Clostridium
botulinum and other clostridial species, are considered to be the most potent toxin known …