The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

A virus hijacks host cellular machineries and metabolites in order to reproduce. In response,
the innate immune system activates different processes to fight back. Although many aspects …

Translation initiation defines the identity and quantity of a synthesized protein. The process
is dysregulated in many human diseases,. A key commitment step is when the ribosomal …

Summary Nonstructural protein 1 (Nsp1) produced by coronaviruses inhibits host protein
synthesis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp1 C …

All betacoronaviruses (β-CoVs) encode non-structural protein 1 (Nsp1), an essential
pathogenicity factor that potently restricts host gene expression. Among the β-CoV family …

Eukaryotic translation initiation involves recruitment of the 43S pre-initiation complex to the
5′ end of mRNA by the cap-binding complex eIF4F, forming the 48S translation initiation …

The eukaryotic initiation factor 4G2 (eIF4G2, DAP5, Nat1, p97) was discovered in 1997. Over
the past two decades, dozens of papers have presented contradictory data on eIF4G2 …

Protein synthesis by the ribosome requires large-scale rearrangements of the 'small'subunit
(SSU;∼ 1 MDa), including inter-and intra-subunit rotational motions. However, with nearly …

In actively translating 80S ribosomes the ribosomal protein eS7 of the 40S subunit is
monoubiquitinated by the E3 ligase Not4 and deubiquitinated by Otu2 upon ribosomal …

Aberrantly slow ribosomes incur collisions, a sentinel of stress that triggers quality control,
signaling, and translation attenuation. Although each collision response has been studied in …