Emerging role of METTL3 in inflammatory diseases: mechanisms and therapeutic applications

B Song, Y Zeng, Y Cao, J Zhang, C Xu, Y Pan… - Frontiers in …, 2023 - frontiersin.org
Despite improvements in modern medical therapies, inflammatory diseases, such as
atherosclerosis, diabetes, non-alcoholic fatty liver, chronic kidney diseases, and …

RNA modification in cardiovascular disease: implications for therapeutic interventions

C Wang, X Hou, Q Guan, H Zhou, L Zhou… - … and Targeted Therapy, 2023 - nature.com
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …

MetBil as a novel molecular regulator in ischemia‐induced cardiac fibrosis via METTL3‐mediated m6A modification

Y Zhuang, T Li, X Hu, Y Xie, X Pei, C Wang… - The FASEB …, 2023 - Wiley Online Library
Cardiac fibrosis is a common pathological manifestation in multiple cardiovascular diseases
and often results in myocardial stiffness and cardiac dysfunctions. LncRNA (long noncoding …

Down-regulation miR-146a-5p in Schwann cell-derived exosomes induced macrophage M1 polarization by impairing the inhibition on TRAF6/NF-κB pathway after …

J Sun, Z Liao, Z Li, H Li, Z Wu, C Chen, H Wang - Experimental Neurology, 2023 - Elsevier
Abstract Background Both Schwann cell-derived exosomes (SC-Exos) and macrophagic
sub-phenotypes are closely related to the regeneration and repair after peripheral nerve …

Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries

M Tian, L Mao, L Zhang - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Central nervous system (CNS) injuries, including traumatic brain injury (TBI), intracerebral
hemorrhage (ICH) and ischemic stroke, are the most common cause of death and disability …

In Search of a Function for the N6-Methyladenosine in Epitranscriptome, Autophagy and Neurodegenerative Diseases

N Suga, Y Ikeda, S Yoshikawa, K Taniguchi… - Neurology …, 2023 - mdpi.com
Changes in epitranscriptome with N6-methyladenine (m6A) modification could be involved
in the development of multiple diseases, which might be a prevalent modification of …

Landscape of internal N7-methylguanosine of long non-coding RNA modifications in resistant acute myeloid leukemia

J Han, Q Liu, Y Zhou, D Li, R Wang - BMC genomics, 2023 - Springer
Background Growing evidence indicates that RNA methylation plays a fundamental role in
epigenetic regulation, which is associated with the tumorigenesis and drug resistance …

[HTML][HTML] m6A methyltransferase METTL3 contributes to sympathetic hyperactivity post-MI via promoting TRAF6-dependent mitochondrial ROS production

P Yang, Y Wang, W Ge, Y Jing, H Hu, J Yin… - Free Radical Biology …, 2023 - Elsevier
Abstract Objectives N6-methyladenosine (m6A) is the most prevalent post-translational
modification in eukaryotic mRNA. Recently, m6A editing modified by methyltransferase-like …

[HTML][HTML] Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching

Z Tang, J Xie, M Jin, G Wei, Z Fu, X Luo, C Li… - Journal of Advanced …, 2024 - Elsevier
Introduction Sympathetic hyperinnervation plays an important role in modulating the
vascular smooth muscle cell (VSMC) phenotype and vascular diseases, but its role in …

N6-methyladenosine (m6A) modification in Natural immune cell-mediated inflammatory diseases

Y Teng, J Yi, J Chen, L Yang - Journal of Innate Immunity, 2023 - karger.com
The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability,
transport, and translation with implications for various physiological and pathological …