The relationship between UGT1A1 gene & various diseases and prevention strategies
D Liu, Q Yu, Q Ning, Z Liu, J Song - Drug Metabolism Reviews, 2022 - Taylor & Francis
Abstract UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic
enzyme family and the only enzyme that can metabolize detoxified bilirubin. Inactivation and …
enzyme family and the only enzyme that can metabolize detoxified bilirubin. Inactivation and …
Association of UGT1A1* 6 polymorphism with irinotecan-based chemotherapy reaction in colorectal cancer patients: a systematic review and a meta-analysis
X Zhu, R Ma, X Ma, G Yang - Bioscience Reports, 2020 - portlandpress.com
Colorectal cancer (CRC) is a leading cause of cancer-related deaths across the world.
Irinotecan (IRI) is commonly used to treat CRC, and IRI-based chemotherapy is linked with …
Irinotecan (IRI) is commonly used to treat CRC, and IRI-based chemotherapy is linked with …
The Genetics of Glucose-6-Phosphate-Dehydrogenase (G6PD) and uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) promoter gene polymorphism in …
A Riskin, Y Bravdo, C Habib, I Maor, J Mousa… - Children, 2023 - mdpi.com
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and polymorphism in uridine
diphosphate glucuronosyl transferase 1A1 (UGT1A1) were associated with significant …
diphosphate glucuronosyl transferase 1A1 (UGT1A1) were associated with significant …
Bilirubin metabolism and UDP‐glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response
MJ Huang, PL Chen, CS Huang - The Kaohsiung Journal of …, 2022 - Wiley Online Library
In the Asian general population, at least six single‐nucleotide variants (SNVs) in the UDP‐
glucuronosyltransferase (UGT) 1A1 gene have been identified:− 3279T> G,− 53A (TA) …
glucuronosyltransferase (UGT) 1A1 gene have been identified:− 3279T> G,− 53A (TA) …
中国西南地区新生儿高胆红素血症基因多态性研究
刘玲， 蒋榆辉， 聂潘荣， 曾丽梅， 段改原… - 临床儿科 …, 2022 - jcp.xinhuamed.com.cn
目的探讨尿苷二磷酸葡萄糖醛基转移酶1A1 (UGT1A1), 有机阴离子转运体1B1 (SLCO1B1)
及葡萄糖-6-磷酸脱氢酶(G6PD) 基因多态性与中国西南地区新生儿高胆红素血症的易感关联性 …
及葡萄糖-6-磷酸脱氢酶(G6PD) 基因多态性与中国西南地区新生儿高胆红素血症的易感关联性 …
The role of UGT1A1 (c.-3279 T> G) gene polymorphisms in neonatal hyperbilirubinemia susceptibility
Z Li, L Song, L Hao - BMC Medical Genetics, 2020 - Springer
Background Neonatal hyperbilirubinemia (NNH) is a common disease in newborns. This
research study aimed to assess the associations between uridine diphospho-glucuronate …
research study aimed to assess the associations between uridine diphospho-glucuronate …
[HTML][HTML] Analysis of UGT1A1 genotype-phenotype correlation in Chinese patients with gilbert and crigler-Najjar II syndrome
L Wu, Z Li, Y Song, Y Li, W Zhang, X Zhong… - European Journal of …, 2024 - Elsevier
The spectrum of UDP-glucuronosyltransferase (UGT1A1) variants, which are associated
with Gilbert syndrome (GS) and Crigler-Najjar syndrome (CNS-II), has been reported in …
with Gilbert syndrome (GS) and Crigler-Najjar syndrome (CNS-II), has been reported in …
Associations between UGT1A1 and SLCO1B1 polymorphisms and susceptibility to neonatal hyperbilirubinemia in Thai population
C Atasilp, J Kanjanapipak, J Vichayaprasertkul, P Jinda… - BMC pediatrics, 2022 - Springer
Hyperbilirubinemia is the main mechanism that causes neonatal jaundice, and genetics is
one of the risk factors of hyperbilirubinemia. Therefore, this study aims to explore the …
one of the risk factors of hyperbilirubinemia. Therefore, this study aims to explore the …
[HTML][HTML] Molecular biology of glucose-6-phosphate dehydrogenase and UDP-glucuronosyltransferase 1A1 in the development of neonatal unconjugated …
YL Hung, PF Chang, CS Huang - Pediatrics & Neonatology, 2024 - Elsevier
Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency and variants of the UDP-
glucuronosyltransferase 1A1 (UGT1A1) gene are the most common genetic causes of …
glucuronosyltransferase 1A1 (UGT1A1) gene are the most common genetic causes of …
[HTML][HTML] Effects of variation status and enzyme activity for UDP-glucuronosyltransferase 1A1 gene on neonatal hyperbilirubinemia
MJ Huang, YC Lin, K Liu, PF Chang, CS Huang - Pediatrics & Neonatology, 2020 - Elsevier
Background We found that Taiwanese adults carrying genotypes of UDP-
glucuronosyltransferase (UGT) 1A1 with enzyme activity≤ 40% of normal were at high risk …
glucuronosyltransferase (UGT) 1A1 with enzyme activity≤ 40% of normal were at high risk …