The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …

The rhodopsin crystal structure provides a structural basis for understanding the function of
this and other G protein–coupled receptors (GPCRs). The major structural motifs observed …

Following exposure of our eye to very intense illumination, we experience a greatly elevated
visual threshold, that takes tens of minutes to return completely to normal. The slowness of …

Vitamin A (all-trans-retinol, 1, Figure 1) is considered the most multifunctional vitamin in the
human body. 1 It plays key roles in many physiological processes such as vision …

Mitochondrial dysfunctions have been implicated in the pathophysiology of several age-
related diseases including age-related macular degeneration (AMD), a progressive …

purpose. Provide a reproducible method for culturing confluent monolayers of hfRPE cells
that exhibit morphology, physiology, polarity, and protein expression patterns similar to …

Vitamins A and E are essential, naturally occurring, fat-soluble nutrients that are involved in
several important biological processes such as immunity, protection against tissue damage …

Mitochondrial complex I dysfunction is regarded as underlying dopamine neuron death in
Parkinson's disease models. However, inactivation of the Ndufs4 gene, which compromises …

For over 30 years, photoreceptors have been an outstanding model system for elucidating
basic principles in sensory transduction and G protein signaling. Recently, photoreceptors …