Enteroendocrine cells (EECs) are an essential interface between the gut and brain that
communicate signals about nutrients, pain, and even information from our microbiome …

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic
inflammation. Immune dysfunction is an essential mechanism in the pathogenesis of RA and …

The choroid plexus (CP) epithelium plays a major role in the production of cerebrospinal
fluid (CSF). A polarized cell line, the porcine CP-Riems (PCP-R) line, which exhibits many of …

Several potassium channels (KCs) have been described throughout the gastrointestinal
tract. Notwithstanding, their contribution to both physiologic and pathophysiologic …

The electrical output of neurons relies critically on voltage-and calcium-gated ion channels.
The traditional view of ion channels is that they operate independently of each other in the …

The parasite Entamoeba histolytica kills human cells resulting in ulceration, inflammation
and invasion of the colonic epithelium. We used the cytotoxic properties of ameba to select a …

TRAM-34, a clotrimazole analog characterized as a potent and selective inhibitor of
intermediate-conductance, calcium-activated K+ (IKCa) channels, has been used …

Although both Kcnn4c and Kcnma1 channels are present on colonic mucosal membranes,
only Kcnma1 has been suggested to mediate K+ secretion in the colon. Therefore, studies …

Diarrhea remains a continuous threat to human health worldwide. Scaling up the best
practices for diarrhea prevention requires improved therapies. Diarrhea results from …

Abstract The KCa3. 1 channel (also known as the KCNN4, IK1, or SK4 channel) is an
intermediate-conductance calcium-activated potassium channel that regulates the …