Small RNAs, large networks: posttranscriptional regulons in gram-negative bacteria

K Papenfort, S Melamed - Annual review of microbiology, 2023 - annualreviews.org
Small regulatory RNA (sRNAs) are key mediators of posttranscriptional gene control in
bacteria. Assisted by RNA-binding proteins, a single sRNA often modulates the expression …

Envelope stress responses: balancing damage repair and toxicity

AM Mitchell, TJ Silhavy - Nature Reviews Microbiology, 2019 - nature.com
The Gram-negative envelope is a complex structure that consists of the inner membrane, the
periplasm, peptidoglycan and the outer membrane, and protects the bacterial cell from the …

Global mapping of small RNA-target interactions in bacteria

S Melamed, A Peer, R Faigenbaum-Romm, YE Gatt… - Molecular cell, 2016 - cell.com
Small RNAs (sRNAs) associated with the RNA chaperon protein Hfq are key
posttranscriptional regulators of gene expression in bacteria. Deciphering the sRNA-target …

Trans-Acting Small RNAs and Their Effects on Gene Expression in Escherichia coli and Salmonella enterica

J Hör, G Matera, J Vogel, S Gottesman, G Storz - EcoSal Plus, 2020 - Am Soc Microbiol
The last few decades have led to an explosion in our understanding of the major roles that
small regulatory RNAs (sRNAs) play in regulatory circuits and the responses to stress in …

Bacterial RNA biology on a genome scale

J Hör, SA Gorski, J Vogel - Molecular cell, 2018 - cell.com
Bacteria are an exceedingly diverse group of organisms whose molecular exploration is
experiencing a renaissance. While the classical view of bacterial gene expression was …

In vivo RNA interactome profiling reveals 3'UTR-processed small RNA targeting a central regulatory hub

F Liu, Z Chen, S Zhang, K Wu, C Bei, C Wang… - Nature …, 2023 - nature.com
Small noncoding RNAs (sRNAs) are crucial regulators of gene expression in bacteria.
Acting in concert with major RNA chaperones such as Hfq or ProQ, sRNAs base-pair with …

An overview of gene regulation in bacteria by small RNAs derived from mRNA 3′ ends

F Ponath, J Hör, J Vogel - FEMS microbiology reviews, 2022 - academic.oup.com
Over the past two decades, small noncoding RNAs (sRNAs) that regulate mRNAs by short
base pairing have gone from a curiosity to a major class of post-transcriptional regulators in …

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

EM Hart, AM Mitchell, A Konovalova… - Proceedings of the …, 2019 - National Acad Sciences
The development of new antimicrobial drugs is a priority to combat the increasing spread of
multidrug-resistant bacteria. This development is especially problematic in gram-negative …

Maintaining integrity under stress: envelope stress response regulation of pathogenesis in gram-negative bacteria

CL Hews, T Cho, G Rowley, TL Raivio - Frontiers in cellular and …, 2019 - frontiersin.org
The Gram-negative bacterial envelope is an essential interface between the intracellular
and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the …

Integration of bacterial small RNAs in regulatory networks

M Nitzan, R Rehani, H Margalit - Annual review of biophysics, 2017 - annualreviews.org
Small RNAs (sRNAs) are central regulators of gene expression in bacteria, controlling target
genes posttranscriptionally by base pairing with their mRNAs. sRNAs are involved in many …