Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …

The temperature of a solid tumor is often dissimilar to baseline body temperature and,
compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of …

Currently, gapmer antisense oligonucleotide (ASO) therapeutics are under clinical
development for the treatment of various diseases, including previously intractable human …

Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of
dopaminergic neurons in the substantia nigra. A characteristic pathological feature of PD is …

Patients with peritoneal metastasis of gastric cancer have dismal prognosis, mainly because
of inefficient systemic delivery of drugs to peritoneal tumors. We aimed to develop an …

Background Angiogenesis is important for the progression of gastric cancer (GC). Y-box
binding protein 1 (YB-1) predicts advanced disease and indicates neovasculature formation …

Background Antisense oligonucleotide (ASO) medicine for clinical applications has been
becoming a reality. We previously developed a gapmer ASO targeting Ser/Arg repetitive …

Tissue vascularization through the process of angiogenesis ensures adequate oxygen and
nutrient supply during development and regeneration. The complex morphogenetic events …

Colorectal cancer (CRC) is the third most common cancer and has the second highest
mortality rate among cancers. The development of CRC involves both genetic and …

Abstract Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions
between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover …