In a complex system of interrelated reactions, the heart converts chemical energy to
mechanical energy. Energy transfer is achieved through coordinated activation of enzymes …

Most aspects of energy metabolism display clear variations during day and night. This daily
rhythmicity of metabolic functions, including hormone release, is governed by a circadian …

Driven by autonomous molecular clocks that are synchronized by a master pacemaker in the
suprachiasmatic nucleus, cardiac physiology fluctuates in diurnal rhythms that can be partly …

The functional organization of the cardiovascular system shows clear circadian rhythmicity.
These and other circadian rhythms at all levels of organization are orchestrated by a central …

In association with sleep–wake and fasting–feeding cycles, organisms experience dramatic
oscillations in energetic demands and nutrient supply. It is therefore not surprising that …

Circadian clocks are cell autonomous, transcriptionally based, molecular mechanisms that
confer the selective advantage of anticipation, enabling cells/organs to respond to …

Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …

Circadian misalignment has been implicated in the development of obesity, diabetes
mellitus, and cardiovascular disease. Time-of-day–dependent synchronization of organisms …

Background: Considerable evidence suggests that the time of day at which calories are
consumed markedly impacts body weight gain and adiposity. However, a precise …

Circadian rhythm, or daily oscillation, of behaviors and biological processes is a
fundamental feature of mammalian physiology that has developed over hundreds of …