Connections matter− how viruses use cell–cell adhesion components

M Mateo, A Generous, PL Sinn… - Journal of cell …, 2015 - journals.biologists.com
The epithelium is a highly organized type of animal tissue. Except for blood and lymph
vessels, epithelial cells cover the body, line its cavities in single or stratified layers and …

Experimental models of hepatitis B and C—new insights and progress

E Thomas, TJ Liang - Nature reviews Gastroenterology & hepatology, 2016 - nature.com
Viral hepatitis is a major cause of morbidity and mortality, affecting hundreds of millions of
people worldwide. Hepatitis-causing viruses initiate disease by establishing both acute and …

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

KM Adams Waldorf, JE Stencel-Baerenwald… - Nature medicine, 2016 - nature.com
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a
pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved …

[PDF][PDF] Safety and efficacy of current direct‐acting antiviral regimens in kidney and liver transplant recipients with hepatitis C: results from the HCV‐TARGET study

V Saxena, V Khungar, EC Verna, J Levitsky… - …, 2017 - Wiley Online Library
Data outside of clinical trials with direct‐acting antiviral regimens with or without ribavirin as
treatment of chronic hepatitis C virus in solid organ transplant recipients are limited. Liver …

The impact of hepatitis C virus entry on viral tropism

Q Ding, M Von Schaewen, A Ploss - Cell host & microbe, 2014 - cell.com
Uptake of hepatitis C virus (HCV) into hepatocytes is an orchestrated process, involving
numerous host factors, virion-associated lipoproteins, and a growing number of cell …

Animal models used in hepatitis C virus research

KA Berggren, S Suzuki, A Ploss - International journal of molecular …, 2020 - mdpi.com
The narrow range of species permissive to infection by hepatitis C virus (HCV) presents a
unique challenge to the development of useful animal models for studying HCV, as well as …

[PDF][PDF] HepG2 cells mount an effective antiviral interferon‐lambda based innate immune response to hepatitis C virus infection

B Israelow, CM Narbus, M Sourisseau, MJ Evans - Hepatology, 2014 - Wiley Online Library
Hepatitis C virus (HCV) exposure leads to persistent life‐long infections characterized by
chronic inflammation often developing into cirrhosis and hepatocellular carcinoma. The …

Current status and future development of infectious cell-culture models for the major genotypes of hepatitis C virus: essential tools in testing of antivirals and emerging …

S Ramirez, J Bukh - Antiviral research, 2018 - Elsevier
In this review, we summarize the relevant scientific advances that led to the development of
infectious cell culture systems for hepatitis C virus (HCV) with the corresponding challenges …

Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors

B Israelow, G Mullokandov, J Agudo… - Nature …, 2014 - nature.com
Hepatitis C virus (HCV) replication is dependent on a liver-specific microRNA (miRNA), miR-
122. A recent clinical trial reported that transient inhibition of miR-122 reduced viral titres in …

Animal models to study hepatitis C virus infection

R Burm, L Collignon, AA Mesalam… - Frontiers in …, 2018 - frontiersin.org
With more than 71 million chronically infected people, the hepatitis C virus (HCV) is a major
global health concern. Although new direct acting antivirals have significantly improved the …