Methodological consensus on clinical proton MRS of the brain: Review and recommendations

M Wilson, O Andronesi, PB Barker… - Magnetic resonance …, 2019 - Wiley Online Library
Proton MRS (1H MRS) provides noninvasive, quantitative metabolite profiles of tissue and
has been shown to aid the clinical management of several brain diseases. Although most …

Glutamate and glutamine: a review of in vivo MRS in the human brain

S Ramadan, A Lin, P Stanwell - NMR in Biomedicine, 2013 - Wiley Online Library
Our understanding of the roles that the amino acids glutamate (Glu) and glutamine (Gln)
play in the mammalian central nervous system has increased rapidly in recent times. Many …

MR spectroscopic imaging: principles and recent advances

S Posse, R Otazo, SR Dager… - Journal of Magnetic …, 2013 - Wiley Online Library
MR spectroscopic imaging (MRSI) has become a valuable tool for quantifying metabolic
abnormalities in human brain, prostate, breast and other organs. It is used in routine clinical …

MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T

R Mekle, V Mlynárik, G Gambarota… - … in Medicine: An …, 2009 - Wiley Online Library
Recently, the spin‐echo full‐intensity acquired localized (SPECIAL) spectroscopy technique
was proposed to unite the advantages of short TEs on the order of milliseconds (ms) with full …

In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T

I Tkáč, G Öz, G Adriany, K Uğurbil… - Magnetic Resonance in …, 2009 - Wiley Online Library
A comprehensive comparative study of metabolite quantification from the human brain was
performed on the same 10 subjects at 4T and 7T using MR scanners with identical consoles …

A subspace approach to high‐resolution spectroscopic imaging

F Lam, ZP Liang - Magnetic resonance in medicine, 2014 - Wiley Online Library
Purpose To accelerate spectroscopic imaging using sparse sampling of‐space and
subspace (or low‐rank) modeling to enable high‐resolution metabolic imaging with good …

Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations

AA Maudsley, OC Andronesi, PB Barker… - NMR in …, 2021 - Wiley Online Library
Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for
monitoring metabolic alterations associated with disease or injury; however, to date, these …

Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania

D Öngür, JE Jensen, AP Prescot, C Stork, M Lundy… - Biological …, 2008 - Elsevier
BACKGROUND: At excitatory synapses, glutamate released from neurons is taken up by
glial cells and converted to glutamine, which is cycled back to neurons. Alterations in this …

Localized 1H NMR spectroscopy in different regions of human brain in vivo at 7 T: T2 relaxation times and concentrations of cerebral metabolites

M Marjańska, EJ Auerbach, R Valabrègue… - NMR in …, 2012 - Wiley Online Library
At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral
quality sufficient to quantify 16 metabolites have been obtained previously only in the …

Slice‐selective FID acquisition, localized by outer volume suppression (FIDLOVS) for 1H‐MRSI of the human brain at 7 T with minimal signal loss

A Henning, A Fuchs, JB Murdoch… - NMR in Biomedicine …, 2009 - Wiley Online Library
Abstract In comparison to 1.5 and 3 T, MR spectroscopic imaging at 7 T benefits from signal‐
to‐noise ratio (SNR) gain and increased spectral resolution and should enable mapping of a …