Embryonic myogenesis is a temporally and spatially regulated process that generates
skeletal muscle of the trunk and limbs. During this process, mononucleated myoblasts …

The Xenopus tadpole model offers many advantages for studying the molecular, cellular and
network mechanisms underlying neurodevelopmental disorders. Essentially every stage of …

Mutations in the Lamin A/C (LMNA) gene-encoding nuclear LMNA cause laminopathies,
which include partial lipodystrophies associated with metabolic syndromes. The …

Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-
binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; …

The axons of retinal ganglion cells (RGCs) are topographically sorted before they arrive at
the optic tectum. This pre-target sorting, typical of axon tracts throughout the brain, is poorly …

Rbfox RNA binding proteins are implicated as regulators of phylogenetically-conserved
alternative splicing events important for muscle function. To investigate the function of rbfox …

In vivo, RNA molecules are constantly accompanied by RNA binding proteins (RBPs), which
are intimately involved in every step of RNA biology, including transcription, editing, splicing …

The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1
gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of …

FMR1 and FXR1 are RNA binding proteins interacting with the miRNA-induced silencing
complex, RISC. Here we describe for the first time the function of these proteins during eye …

Alternative splicing of pre-mRNAs is a major contributor to proteomic diversity and to the
control of gene expression in higher eukaryotic cells. For this reasons, alternative splicing is …