[HTML][HTML] Neuronal sigma-1 receptors: signaling functions and protective roles in neurodegenerative diseases
DA Ryskamp, S Korban, V Zhemkov… - Frontiers in …, 2019 - frontiersin.org
Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
[HTML][HTML] BDNF signaling during the lifetime of dendritic spines
M Zagrebelsky, C Tacke, M Korte - Cell and Tissue Research, 2020 - Springer
Dendritic spines are tiny membrane specialization forming the postsynaptic part of most
excitatory synapses. They have been suggested to play a crucial role in regulating synaptic …
excitatory synapses. They have been suggested to play a crucial role in regulating synaptic …
Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior
Haploinsufficiency of the AT-rich interactive domain 1B (ARID1B) gene causes autism
spectrum disorder and intellectual disability; however, the neurobiological basis for this is …
spectrum disorder and intellectual disability; however, the neurobiological basis for this is …
[HTML][HTML] The effects of psychedelics on neuronal physiology
CJ Hatzipantelis, DE Olson - Annual Review of Physiology, 2024 - annualreviews.org
Psychedelics are quite unique among drugs that impact the central nervous system, as a
single administration of a psychedelic can both rapidly alter subjective experience in …
single administration of a psychedelic can both rapidly alter subjective experience in …
[HTML][HTML] 2-Phenylethylamine (PEA) ameliorates corticosterone-induced depression-like phenotype via the BDNF/TrkB/CREB signaling pathway
Depression is a serious medical illness that is one of the most prevalent psychiatric
disorders. Corticosterone (CORT) increases depression-like behavior, with some effects on …
disorders. Corticosterone (CORT) increases depression-like behavior, with some effects on …
[HTML][HTML] Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model
Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting
both the upper and lower motor neurons (MNs), with no effective treatment currently …
both the upper and lower motor neurons (MNs), with no effective treatment currently …
ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway
Haploinsufficiency of ANKRD11 due to deletion or truncation mutations causes KBG
syndrome, a rare genetic disorder characterized by intellectual disability, autism spectrum …
syndrome, a rare genetic disorder characterized by intellectual disability, autism spectrum …
Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics
Although cocaine exposure has been shown to potentiate neuroinflammation by
upregulating glial activation in the brain, the role of mitophagy in this process remains an …
upregulating glial activation in the brain, the role of mitophagy in this process remains an …
[HTML][HTML] Inhibition of CSF1R, a receptor involved in microglia viability, alters behavioral and molecular changes induced by cocaine
MCM da Silva, GF Gomes, H de Barros Fernandes… - Scientific reports, 2021 - nature.com
Different data suggest that microglia may participate in the drug addiction process as these
cells respond to neurochemical changes induced by the administration of these substances …
cells respond to neurochemical changes induced by the administration of these substances …
Cocaine mediated neuroinflammation: role of dysregulated autophagy in pericytes
Cocaine, a known psychostimulant, results in oxidative stress and inflammation. Recent
studies from our group have shown that cocaine induces inflammation in glial cells. Our …
studies from our group have shown that cocaine induces inflammation in glial cells. Our …