Animal models for COVID-19: advances, gaps and perspectives
C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models
R Butowt, N Meunier, B Bryche, CS von Bartheld - Acta neuropathologica, 2021 - Springer
One of the most frequent symptoms of COVID-19 is the loss of smell and taste. Based on the
lack of expression of the virus entry proteins in olfactory receptor neurons, it was originally …
lack of expression of the virus entry proteins in olfactory receptor neurons, it was originally …
Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia
Although microbial populations in the gut microbiome are associated with COVID-19
severity, a causal impact on patient health has not been established. Here we provide …
severity, a causal impact on patient health has not been established. Here we provide …
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice
KH Dinnon III, SR Leist, K Okuda, H Dang… - Science translational …, 2022 - science.org
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model
SN Langel, S Johnson, CI Martinez… - Science Translational …, 2022 - science.org
Transmission-blocking strategies that slow the spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and protect against coronavirus disease 2019 (COVID-19) are …
coronavirus 2 (SARS-CoV-2) and protect against coronavirus disease 2019 (COVID-19) are …
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters
Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The
relative contribution of different transmission routes remains subject to debate. Here, we …
relative contribution of different transmission routes remains subject to debate. Here, we …
The K18-human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus
ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma
J Geng, L Chen, Y Yuan, K Wang, Y Wang… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,
compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth …
compromising the effectiveness of existing vaccines and neutralizing antibodies. An in-depth …
[HTML][HTML] The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human …
RMLC Biancatelli, PA Solopov… - … of Physiology-Lung …, 2021 - journals.physiology.org
Acute lung injury (ALI) leading to acute respiratory distress syndrome is the major cause of
COVID-19 lethality. Cell entry of SARS-CoV-2 occurs via the interaction between its surface …
COVID-19 lethality. Cell entry of SARS-CoV-2 occurs via the interaction between its surface …