Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …

Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …

Netrin-4, a member of the Netrins family, is an important secreted protein that plays a role in
axonal outgrowth and migration orientation. It was initially described that Netrin-4 had a high …

Background Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized
by pathogenic remodeling of pulmonary arterioles leading to increased pulmonary …

Congenital abnormalities of the kidney and urinary tract are among the most common birth
defects, affecting 3% of newborns. The human kidney forms around a million nephrons from …

The differentiation of human pluripotent stem cells (hPSCs) towards organoids is one of the
biggest scientific advances in regenerative medicine. Kidney organoids have not only laid …

The application of organoids has been limited by the lack of methods for producing uniformly
mature organoids at scale. This study introduces an organoid culture platform, called …

Natriuretic peptide receptor-A (NPR-A) is the principal receptor for the natriuretic peptides
atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Targeted deletion of NPR …

Purpose of review The current paradigm of idiopathic pulmonary fibrosis (IPF) pathogenesis
involves recurrent injury to a sensitive alveolar epithelium followed by impaired repair …

The study aimed to investigate the effect of methionine deficiency on conventional nutrient
composition, NO and NOS activity in the liver and kidney, and expression of genes related to …