Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

[HTML][HTML] Astrocytic activation generates de novo neuronal potentiation and memory enhancement

A Adamsky, A Kol, T Kreisel, A Doron… - Cell, 2018 - cell.com
Astrocytes respond to neuronal activity and were shown to be necessary for plasticity and
memory. To test whether astrocytic activity is also sufficient to generate synaptic potentiation …

Bidirectional microglia–neuron communication in health and disease

Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

The role of cytokines in modulating learning and memory and brain plasticity

JM Bourgognon, J Cavanagh - Brain and neuroscience …, 2020 - journals.sagepub.com
Cytokines are proteins secreted in the central nervous system by neurons, microglia,
astrocytes and infiltrating peripheral immune cells under physiological and pathological …

Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?

H Targa Dias Anastacio, N Matosin, L Ooi - Translational psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …

Astrocyte calcium signaling: the third wave

N Bazargani, D Attwell - Nature neuroscience, 2016 - nature.com
The discovery that transient elevations of calcium concentration occur in astrocytes, and
release'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea …

Diversity and specificity of astrocyte–neuron communication

CA Durkee, A Araque - Neuroscience, 2019 - Elsevier
Astrocytes are emerging as important players in synaptic function, and, consequently, on
brain function and animal behavior. According to the Tripartite Synapse concept, astrocytes …

Inflammation, glutamate, and glia: a trio of trouble in mood disorders

E Haroon, AH Miller, G Sanacora - Neuropsychopharmacology, 2017 - nature.com
Increasing data indicate that inflammation and alterations in glutamate neurotransmission
are two novel pathways to pathophysiology in mood disorders. The primary goal of this …

Gliotransmission: beyond black-and-white

I Savtchouk, A Volterra - Journal of Neuroscience, 2018 - Soc Neuroscience
Astrocytes are highly complex cells with many emerging putative roles in brain function. Of
these, gliotransmission (active information transfer from glia to neurons) has probably the …