Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Minimal change disease (MCD) is a major cause of idiopathic nephrotic syndrome (NS),
characterized by intense proteinuria leading to edema and intravascular volume depletion …

Nephrotic syndrome is a highly prevalent disease that is associated with high morbidity
despite notable advances in its treatment. Many of the complications of nephrotic syndrome …

Focal segmental glomerulosclerosis, which is characterized by progressive glomerular
scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in …

Results In 74 of 300 families (25%), we identified a causative mutation in one of 20 genes
known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a …

Most glomerulonephritides, even the more common types, are rare diseases. They are
nevertheless important since they frequently affect young people, often cannot be cured, and …

Background Rituximab could be an effective treatment for childhood-onset, complicated,
frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic …

As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …