Podocytopathies
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
[HTML][HTML] Minimal change disease
M Vivarelli, L Massella, B Ruggiero… - Clinical Journal of the …, 2017 - journals.lww.com
Minimal change disease (MCD) is a major cause of idiopathic nephrotic syndrome (NS),
characterized by intense proteinuria leading to edema and intravascular volume depletion …
characterized by intense proteinuria leading to edema and intravascular volume depletion …
Dyslipidaemia in nephrotic syndrome: mechanisms and treatment
S Agrawal, JJ Zaritsky, A Fornoni… - Nature Reviews …, 2018 - nature.com
Nephrotic syndrome is a highly prevalent disease that is associated with high morbidity
despite notable advances in its treatment. Many of the complications of nephrotic syndrome …
despite notable advances in its treatment. Many of the complications of nephrotic syndrome …
Focal segmental glomerulosclerosis
VD D'Agati, FJ Kaskel, RJ Falk - New England Journal of …, 2011 - Mass Medical Soc
Focal segmental glomerulosclerosis, which is characterized by progressive glomerular
scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in …
scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in …
Whole exome sequencing of patients with steroid-resistant nephrotic syndrome
JK Warejko, W Tan, A Daga, D Schapiro… - Clinical Journal of the …, 2018 - journals.lww.com
Results In 74 of 300 families (25%), we identified a causative mutation in one of 20 genes
known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a …
known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a …
Primary glomerulonephritides
J Floege, K Amann - The Lancet, 2016 - thelancet.com
Most glomerulonephritides, even the more common types, are rare diseases. They are
nevertheless important since they frequently affect young people, often cannot be cured, and …
nevertheless important since they frequently affect young people, often cannot be cured, and …
Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind …
Background Rituximab could be an effective treatment for childhood-onset, complicated,
frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic …
frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic …
Cell biology and pathology of podocytes
A Greka, P Mundel - Annual review of physiology, 2012 - annualreviews.org
As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …
unique geographical position: It is exposed to chemical signals from the urinary space …
Regulation of the actin cytoskeleton in podocytes
J Blaine, J Dylewski - Cells, 2020 - mdpi.com
Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …
filtration of large proteins and macromolecules into the urine. Podocyte function is …