Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …

Systematic evolution of ligands by exponential enrichment (SELEX) is a well-established
and efficient technology for the generation of oligonucleotides with a high target affinity …

One hundred years ago, Dr. Paul Ehrlich popularized the" magic bullet" concept for cancer
therapy in which an ideal therapeutic agent would only kill the specific tumor cells it targeted …

Affinity reagents are essential tools in both basic and applied research; however, there is a
growing concern about the reproducibility of animal-derived monoclonal antibodies. The …

The enzymatic co-polymerization of modified nucleoside triphosphates (dN* TPs and N*
TPs) is a versatile method for the expansion and exploration of expanded chemical space in …

Aptamers are single-stranded oligonucleotides (RNA or DNA) with a typical length between
25 and 100 nucleotides which fold into three-dimensional structures capable of binding to …

DNA aptamers have potential for disease diagnosis and as therapeutics, particularly when
interfaced with programmable molecular technology. Here we have combined DNA …

Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐
tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell …

Biomimetic binders and catalysts have been generated in order to substitute the biological
pendants in separation techniques and bioanalysis. The two major approaches use either …

Troponin T and I are ideal markers which are highly sensitive and specific for myocardial
injury and have shown better efficacy than earlier markers. Since aptamers are ssDNA or …