Epidemiology, pathophysiology, diagnosis, and management of cerebral toxoplasmosis
HM Elsheikha, CM Marra, XQ Zhu - Clinical microbiology reviews, 2020 - Am Soc Microbiol
Toxoplasma gondii is known to infect a considerable number of mammalian and avian
species and a substantial proportion of the world's human population. The parasite has an …
species and a substantial proportion of the world's human population. The parasite has an …
CRISPR-Cas9 system: A new-fangled dawn in gene editing
Till date, only three techniques namely Zinc Finger Nuclease (ZFN), Transcription-Activator
Like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic …
Like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic …
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
Vaccines have had broad medical impact, but existing vaccine technologies and production
methods are limited in their ability to respond rapidly to evolving and emerging pathogens …
methods are limited in their ability to respond rapidly to evolving and emerging pathogens …
[HTML][HTML] A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes
Apicomplexan parasites are leading causes of human and livestock diseases such as
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …
[HTML][HTML] Origins of programmable nucleases for genome engineering
S Chandrasegaran, D Carroll - Journal of molecular biology, 2016 - Elsevier
Genome engineering with programmable nucleases depends on cellular responses to a
targeted double-strand break (DSB). The first truly targetable reagents were the zinc finger …
targeted double-strand break (DSB). The first truly targetable reagents were the zinc finger …
Identification of a master regulator of differentiation in Toxoplasma
Toxoplasma gondii chronically infects a quarter of the world's population, and its
recrudescence can cause life-threatening disease in immunocompromised individuals and …
recrudescence can cause life-threatening disease in immunocompromised individuals and …
Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum
Recent studies into the global causes of severe diarrhoea in young children have identified
the protozoan parasite Cryptosporidium as the second most important diarrhoeal pathogen …
the protozoan parasite Cryptosporidium as the second most important diarrhoeal pathogen …
EuPaGDT: a web tool tailored to design CRISPR guide RNAs for eukaryotic pathogens
D Peng, R Tarleton - Microbial genomics, 2015 - microbiologyresearch.org
Recent development of CRISPR-Cas9 genome editing has enabled highly efficient and
versatile manipulation of a variety of organisms and adaptation of the CRISPR-Cas9 system …
versatile manipulation of a variety of organisms and adaptation of the CRISPR-Cas9 system …
[HTML][HTML] The Toxoplasma dense granule proteins GRA17 and GRA23 mediate the movement of small molecules between the host and the parasitophorous vacuole
Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within
an intracellular parasitophorous vacuole (PV) that is selectively permeable to small …
an intracellular parasitophorous vacuole (PV) that is selectively permeable to small …
Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii
Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …