[HTML][HTML] Current perspectives on statins as potential anti-cancer therapeutics: clinical outcomes and underlying molecular mechanisms

AF Hassanabad - Translational Lung Cancer Research, 2019 - ncbi.nlm.nih.gov
Statins have been shown to inhibit cell proliferation in vitro and tumor growth in animal
models. Various studies have also shown a decreased cancer-specific mortality rate in …

Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer

P Huang, X Fan, H Yu, K Zhang, H Li, Y Wang… - Journal of Translational …, 2023 - Springer
Endometrial cancer (EC) is a common gynecological cancer that endangers women health.
Although substantial progresses of EC management have been achieved in recent years …

Etiological relationship between lipid metabolism and endometrial carcinoma

W Li, Y Xu, X Zeng, J Tan, Y Wang, H Wu, M Li… - Lipids in Health and …, 2023 - Springer
Endometrial carcinoma (EC) has become one of the most common gynecological malignant
neoplasms in developed countries worldwide. Studies have shown that this may be closely …

Cholesterol metabolism in drug‑resistant cancer

A Yan, Z Jia, C Qiao, M Wang… - … Journal of Oncology, 2020 - spandidos-publications.com
Cancer represents a severe challenge to healthcare systems and individuals worldwide.
The development of multiple drug resistance is a major issue regarding cancer therapy …

Ovarian conservation for young women with early-stage, low-grade endometrial cancer: a 2-step schema

K Matsuo, RS Mandelbaum, S Matsuzaki, M Klar… - American journal of …, 2021 - Elsevier
In 2020, endometrial cancer continues to be the most common gynecologic malignancy in
the United States. The majority of endometrial cancer is low grade, and nearly 1 of every 8 …

[HTML][HTML] Impact of statin use on cancer-specific mortality and recurrence: A meta-analysis of 60 observational studies

J Yang, C Li, Y Shen, H Zhou, Y Shao, W Zhu, Y Chen - Medicine, 2020 - journals.lww.com
Impact of statin use on cancer-specific mortality and recurr... : Medicine Impact of statin use on
cancer-specific mortality and recurrence: A meta-analysis of 60 observational studies : Medicine …

Statins as repurposed drugs in gynecological cancer: A review

KH Wang, CH Liu, DC Ding - International Journal of Molecular Sciences, 2022 - mdpi.com
Discovering new drugs is an expensive and time-consuming process, including target
identification, bioavailability, pharmacokinetic (PK) tests, pharmacodynamic (PD) tests …

Differences in the microbial profiles of early stage endometrial cancers between Black and White women

GM Hawkins, WC Burkett, AN McCoy, HB Nichols… - Gynecologic …, 2022 - Elsevier
Objective Black women suffer a higher mortality from endometrial cancer (EC) than White
women. Potential biological causes for this disparity include a higher prevalence of obesity …

[HTML][HTML] Ovary and uterus related adverse events associated with statin use: an analysis of the FDA Adverse Event Reporting System

X Jiao, H Li, X Jiao, Y Guo, C Zhang, C Yang, L Zeng… - Scientific reports, 2020 - nature.com
Experimental studies have demonstrated statin-induced toxicity for ovary and uterus.
However, the safety of statins on the functions of ovary and uterus in real-world clinical …

The levels of bioelements in postmenopausal women with metabolic syndrome

AM Cybulska, D Schneider-Matyka, M Bosiacki… - Nutrients, 2022 - mdpi.com
(1) Metabolic syndrome is a set of factors that considerably increase the risk of developing
atherosclerosis, type 2 diabetes, and their cardiovascular complications. Studies show that …